Dec 22, 2022 · It might surprise you how quickly your baby is picking up new skills. Infant development milestones for a 7- to 9-month-old include sitting, standing and laughing. As your baby becomes more mobile and curious, infant development takes off. It might seem that your baby learns something new every day. Signs and symptoms in people over the age of 2 may include: High fever that comes on suddenly. Stiff neck. Severe headache that seems unusual. Headache with nausea or vomiting. Confusion or ...Jun 21, 2021 · through feces, saliva, nasal mucus, sputum, and blister fluid. Epstein-Barr virus: This virus can spread. Trusted Source. through bodily fluids such as saliva. A person can also get it after organ ... Sep 17, 2019 · Summary. Meningitis is inflammation of the thin tissue that surrounds the brain and spinal cord, called the meninges. There are several types of meningitis. The most common is viral meningitis. You get it when a virus enters the body through the nose or mouth and travels to the brain. Bacterial meningitis is rare, but can be deadly. Enteroviruses can be spread when an infected person sneezes or coughs droplets into the air or on surfaces. A child may then breathe in droplets or touch a contaminated surface and touch their eyes, mouth, or nose. The viruses are treated with supportive care, such as fever or pain medicine, rest, and fluids.Viral (aseptic) meningitis. Although very rare, a small number of people with HFMD get viral meningitis. It causes fever, headache, stiff neck, or back pain and may require the infected person to be hospitalized for a few days. Learn more about Viral Meningitis. Encephalitis or paralysisMeningitis in newborns can be either early or late onset. Early onset occurs within the first week after birth for babies born at term, and in the first 72 hours of life for those born preterm ...Meningitis in children. Meningitis becomes more common in children as they grow older and reach high school and college ages. Symptoms of viral and bacterial meningitis in children are similar to ...Feb 26, 2018 · Protecting newborns Seeing a doctor Meningitis is a condition that causes inflammation in the meninges, which protect the brain and spinal cord. Meningitis is most often caused by a virus or... Baby & toddler Your baby’s health What to watch out for Meningitis in babies and children What is meningitis? Symptoms What to do if you think your child has meningitis What causes meningitis? How does a baby or child get meningitis?Change in behavior – crying more than usual, irritable, more sleepy, confused. Hearing loss. Severe headaches. Bulging soft spot on their head – babies only. If you suspect your child’s bacterial meningitis is coming back or they are getting sicker, take them to the closest hospital emergency department or call 911. Babies are at high risk of bacterial meningitis and often have symptoms that mimic other illnesses. Parents should be on the lookout for meningitis symptoms such as high fever, stiff neck, rigid extremities, vomiting, diarrhea, or a skin rash with lots of pinpoint-sized dots ( petechiae ) that are associated with invasive meningococcal disease .Children are at a higher risk of meningitis caused by a bacterial or viral infection. Children more likely to get the illness include: Newborns and babies (Because their immune systems are not well developed, the bacteria can get into the bloodstream more easily.) Children with frequent sinus infections Feb 8, 2011 · Newborn babies are immune to some diseases because they have antibodies they get from their mothers, usually before they are born. However, this immunity lasts a few months. Most babies do not get protective antibodies against diphtheria, whooping cough, polio, tetanus, hepatitis B, or Hib from their mothers. Infant development milestones for a 7- to 9-month-old include sitting, standing and laughing. By Mayo Clinic Staff. As your baby becomes more mobile and curious, infant development takes off. It might seem that your baby learns something new every day. Understand these next milestones and what you can do to promote your baby's growth.Signs and symptoms in people over the age of 2 may include: High fever that comes on suddenly. Stiff neck. Severe headache that seems unusual. Headache with nausea or vomiting. Confusion or ...Oct 13, 2021 · Herpes meningitis is a type of viral meningitis resulting from infection with a herpes virus. Three types of herpes virus can cause HM: herpes simplex virus 1, herpes simplex virus 2, and ... Specific Immunization Reactions. Pain or swelling at the shot site for 1 to 2 days. (20% of children) Mild fever lasting 1 to 3 days begins 14 to 28 days after the shot (10%). Give acetaminophen or ibuprofen for fever over 102° F (39°C). Never give aspirin for fever, pain or within 6 weeks of getting the shot.Two serious bacterial infections in a two-year period (meningitis, blood infection, or pneumonia) Swelling of the parotid gland (salivary glands located in front of the ear) Oral thrush that lasts for more than two months. A yeast infection that occurs in the digestive track or lungs. Constant or recurring sinus infections. Constant or ...Feb 6, 2023 · Meningitis is an infection of the membranes that cover the brain and spinal cord. While meningitis affects people in all age groups, children 2 and younger are most at risk. Without prompt treatment, infants with meningitis can suffer permanent brain damage or even death. Learn more about the causes, symptoms, and treatment of this dangerous ... Here we offer helpful, doctor-approved info about fever, coughs, colds, flu, rashes, allergies, and many other health concerns. Explore our guides to doctor visits, vaccines, and medication, get advice on teething and dental care, and learn how to keep your child safe at home and beyond. Photo credit: iStock.com / FatCamera.Bacterial meningitis is a devastating infection associated with high mortality and morbidity in the neonatal population. Prompt diagnosis and treatment are essential to achieving good outcomes in affected infants. While overall incidence and mortality have declined over the last several decades, morbidity associated with neonatal meningitis ... Neonatal meningitis is a serious medical condition in infants that is rapidly fatal if untreated. Meningitis is an inflammation of the meninges , the protective membranes of the central nervous system , is more common in the neonatal period (infants less than 44 days old) than any other time in life, and is an important cause of morbidity and ... Spread to others. People spread meningococcal bacteria to other people by sharing respiratory and throat secretions (saliva or spit). Generally, it takes close (for example, coughing or kissing) or lengthy contact to spread these bacteria. Fortunately, they are not as contagious as germs that cause the common cold or the flu. Here we offer helpful, doctor-approved info about fever, coughs, colds, flu, rashes, allergies, and many other health concerns. Explore our guides to doctor visits, vaccines, and medication, get advice on teething and dental care, and learn how to keep your child safe at home and beyond. Photo credit: iStock.com / FatCamera.Spread to others. People spread meningococcal bacteria to other people by sharing respiratory and throat secretions (saliva or spit). Generally, it takes close (for example, coughing or kissing) or lengthy contact to spread these bacteria. Fortunately, they are not as contagious as germs that cause the common cold or the flu. Here we offer helpful, doctor-approved info about fever, coughs, colds, flu, rashes, allergies, and many other health concerns. Explore our guides to doctor visits, vaccines, and medication, get advice on teething and dental care, and learn how to keep your child safe at home and beyond. Photo credit: iStock.com / FatCamera. Among adults 60 years of age and older, the more common signs and symptoms of hydrocephalus are: Loss of bladder control or a frequent urge to urinate. Memory loss. Progressive loss of other thinking or reasoning skills. Difficulty walking, often described as a shuffling gait or the feeling of the feet being stuck.Meningitis during the neonatal period is a potentially devastating condition with dire long-term consequences. Despite advances in preventive and critical care medicine, bacterial meningitis continues to have an adverse outcome rate of 20 to 60% among its survivors.[1] Although the incidence and mortality have declined over the past few decades, it remains challenging to diagnose due to ...Feb 27, 2018 · Viral meningitis is the most common type, but it’s not usually life-threatening. The enteroviruses that cause meningitis can spread through direct contact with saliva, nasal mucus, or feces ... Child and Adolescent Immunization Schedule by Age. Recommendations for Ages 18 Years or Younger, United States, 2023. Print. Please see the most up-to-date COVID-19 vaccine recommendations and new or updated recommendations for RSV , Influenza, pneumococcal, polio, and Mpox vaccines. These have been adopted by the CDC Director and are official.Feb 6, 2023 · Meningitis is an infection of the membranes that cover the brain and spinal cord. While meningitis affects people in all age groups, children 2 and younger are most at risk. Without prompt treatment, infants with meningitis can suffer permanent brain damage or even death. Learn more about the causes, symptoms, and treatment of this dangerous ... Meningitis In Babies. Meningitis is an inflammation of the meninges, which is the tissue that surrounds and protects the brain and spinal cord. It’s most commonly caused by viral or bacterial infections. Meningitis is a serious condition that, left untreated, can be fatal in a short period of time and can cause life-altering complications in ... The MenB vaccine will protect your baby against infection by meningococcal group B bacteria. These bacteria are responsible for about 9 in every 10 meningococcal infections in young children. Meningococcal infections can be very serious, causing meningitis and sepsis. This can lead to severe brain damage, amputations and, sometimes, death.Sep 15, 2022 · About 2,000 cases of serious disease (bacteremia, pneumonia with bacteremia, and meningitis) occur each year in children under 5 years old in the United States. These illnesses can lead to disabilities like deafness, brain damage, or loss of arms or legs. About 1 out of 12 children who get pneumococcal meningitis dies. Meningitis is an inflammation of the thin membranes that cover the brain and the spinal cord. It is most often caused by a bacterial or viral infection that moves into the cerebral spinal fluid. A fungus or parasite may also cause meningitis. Meningitis caused by a virus is more common and usually less severe.Sep 21, 2021 · In infants, illness caused by group B strep can be within six hours of birth (early onset) — or weeks or months after birth (late onset). Signs and symptoms might include: Fever. Low body temperature. Difficulty feeding. Sluggishness, limpness or weak muscle tone. Difficulty breathing. Irritability. Jitteriness. Meningococcal meningitis and bloodstream infections can be very serious, even deadly. The infections progress quickly. Someone can go from being healthy to very ill in 48 hours or less. Even if they get treatment, about 10 to 15 in 100 people with meningococcal disease will die from it.Signs and symptoms in people over the age of 2 may include: High fever that comes on suddenly. Stiff neck. Severe headache that seems unusual. Headache with nausea or vomiting. Confusion or ...Having convulsions (seizure) Babies who get group B strep a week or so after birth may have signs such as: Decreased movement of an arm or leg. Pain with movement of an arm or leg. Breathing problems. Fever. Red area on the face or other part of the body. Pregnant women may have group B strep without symptoms.Meningitis in children. Meningitis becomes more common in children as they grow older and reach high school and college ages. Symptoms of viral and bacterial meningitis in children are similar to ...Stiff neck. Other symptoms that can occur with this disease: Agitation. Bulging fontanelles in babies. Decreased alertness. Poor feeding or irritability in children. Rapid breathing. Unusual posture, with the head and neck arched backward (opisthotonos) You cannot tell if you have bacterial or viral meningitis by how you feel.Sep 2, 2022 · Meningitis is a serious illness that causes inflammation of the membranes around the spinal cord and neck. It can be fatal without prompt treatment. The meningitis vaccine is one of the best ways ... Meningitis is an inflammation of the meninges (meh-NIN-jeez), the membranes that cover the brain and spinal cord. Some types of meningitis (meh-nen-JYE-tis) can be dangerous and even life-threatening. Routine vaccinations can help prevent it. Quick treatment of meningitis usually is successful. So it's important to know what symptoms it can ... Sep 21, 2021 · In infants, illness caused by group B strep can be within six hours of birth (early onset) — or weeks or months after birth (late onset). Signs and symptoms might include: Fever. Low body temperature. Difficulty feeding. Sluggishness, limpness or weak muscle tone. Difficulty breathing. Irritability. Jitteriness. Meningitis can occur in people of all ages, but babies, children, and those with a weakened immune system are at the highest risk. Babies between birth and 1 month of age are more likely to ...Oct 13, 2021 · Herpes meningitis is a type of viral meningitis resulting from infection with a herpes virus. Three types of herpes virus can cause HM: herpes simplex virus 1, herpes simplex virus 2, and ... Babies who get group B strep a week or so after birth may have signs such as: Decreased movement of an arm or leg. Pain with movement of an arm or leg. Breathing problems. Fever. Red area on the face or other part of the body. Pregnant women may have group B strep without symptoms. When they have symptoms, these may include: Having to urinate ...Pregnant women who are at increased risk for serogroup A, C, W, or Y meningococcal disease may get MenACWY vaccines. Pregnant or breastfeeding women who are at increased risk for serogroup B meningococcal disease may get MenB vaccines. However, they should talk with a doctor to decide if the benefits of getting the vaccine outweigh the risks ...Enteroviruses can be spread when an infected person sneezes or coughs droplets into the air or on surfaces. A child may then breathe in droplets or touch a contaminated surface and touch their eyes, mouth, or nose. The viruses are treated with supportive care, such as fever or pain medicine, rest, and fluids.Feb 27, 2018 · Viral meningitis is the most common type, but it’s not usually life-threatening. The enteroviruses that cause meningitis can spread through direct contact with saliva, nasal mucus, or feces ... Early symptoms will be similar to the flu, and they can develop over a matter of hours or even days. Symptoms include: sudden high fever. stiff neck. severe headache. nausea or vomiting. confusion ...An overview of immunizations for kids ages 4 to 6 years old. DTaP – The fifth and final diphtheria, tetanus and pertussis vaccine is recommended when your child is between 4 and 6 years old. IPV – The poliovirus vaccine is another four-dose series. The dosing schedule for the polio vaccine recommends the first shots at 2 months, 4 months ...Meningitis is an infection of the protective membranes that surround the brain and spinal cord (meninges). It can affect anyone, but is most common in babies, young children, teenagers and young adults. Meningitis can be very serious if not treated quickly. It can cause life-threatening blood poisoning ( sepsis) and result in permanent damage ... Younger kids will need a vaccine if they're at a greater risk of getting meningitis because they: Have complement component deficiency, a rare immune system disease. Have spleen damage or had ... Child and Adolescent Immunization Schedule by Age. Recommendations for Ages 18 Years or Younger, United States, 2023. Print. Please see the most up-to-date COVID-19 vaccine recommendations and new or updated recommendations for RSV , Influenza, pneumococcal, polio, and Mpox vaccines. These have been adopted by the CDC Director and are official.The most common causes of bacterial meningitis among babies younger than 2 months of age are group B Streptococcus, Streptococcus pneumoniae, Listeria monocytogenes, and Escherichia coli .Infants with meningitis can have a variety of symptoms, including: a fever. shivering. a stiff neck. arching of the back. cold hands and feet. turning away from light. excessive irritability, such ...Disease can be localized to skin, eye and mouth (SEM disease), involve the central nervous system (CNS) or manifest as disseminated infection involving multiple organs. Most surviving infants in the latter two categories have neurological sequelae, and the mortality rate in the absence of therapy is very high (80%) for babies in the latter ...Having convulsions (seizure) Babies who get group B strep a week or so after birth may have signs such as: Decreased movement of an arm or leg. Pain with movement of an arm or leg. Breathing problems. Fever. Red area on the face or other part of the body. Pregnant women may have group B strep without symptoms. May 18, 2023 · In many cases, they are harmless. Bacterial meningitis occurs when these bacteria get in your bloodstream and travel to your brain and spinal cord to start an infection. Most bacteria that cause ... Pneumococcal disease can cause infections of the ears, lungs, blood, and brain. Pneumococcal disease is an illness caused by bacteria called pneumococcus. It is often mild, but can cause serious symptoms, lifelong disability, or death. Children younger than 2 years old are among those most at risk for the disease.Older children and adolescents have a stiff neck with a fever, headache, and confusion, and newborns and young infants are usually irritable, stop eating, vomit, or have other symptoms. The diagnosis is based on the results of a spinal tap and blood and urine tests. Some children die of meningitis even after receiving appropriate treatment.In many cases, they are harmless. Bacterial meningitis occurs when these bacteria get in your bloodstream and travel to your brain and spinal cord to start an infection. Most bacteria that cause ...The most common symptoms of meningitis in older children and adults are: fever. sensitivity to light. very bad headache and stiff or sore neck. nausea or vomiting and loss of appetite. tiredness and drowsiness. irritability. confusion. purple-red skin rash or bruising.Prevention. Treatment. Bacterial meningitis is inflammation of the layers of tissue surrounding the brain and spinal cord (meninges) caused by bacteria . Newborns with bacterial meningitis are usually irritable, vomit, or may have seizures. The diagnosis is based on the results of a spinal tap and blood tests.Spinal meningitis is inflammation of the brain and spinal cord due to an infection. Types of meningitis include viral, bacterial, fungal, parasitic, amoebic, and noninfectious. Symptoms typically include headache, fever, and neck stiffness. Treatment depends on the type of meningitis but can include antibiotics, pain relievers, or hospitalization.Meningitis is acute or chronic inflammation of the protective membranes covering the brain and spinal cord, collectively called the meninges. The most common symptoms are fever, headache, and neck stiffness. Other symptoms include confusion or altered consciousness, nausea, vomiting, and an inability to tolerate light or loud noises.Older children and adolescents have a stiff neck with a fever, headache, and confusion, and newborns and young infants are usually irritable, stop eating, vomit, or have other symptoms. The diagnosis is based on the results of a spinal tap and blood and urine tests. Some children die of meningitis even after receiving appropriate treatment. Viral meningitis is an infection of the membranes (linings) that cover the brain and spinal cord. Symptoms and infectious periods vary depending on the virus responsible. Most people recover from viral meningitis. This publication is provided for education and information purposes only. It is not a substitute for professional medical care.Child and Adolescent Immunization Schedule by Age. Recommendations for Ages 18 Years or Younger, United States, 2023. Print. Please see the most up-to-date COVID-19 vaccine recommendations and new or updated recommendations for RSV , Influenza, pneumococcal, polio, and Mpox vaccines. These have been adopted by the CDC Director and are official.Meningitis vaccine schedule for babies or children . The CDC recommends that children receive their first MenACWY vaccine between the ages of 11 and 12. The MenACWY vaccine is a single dose ...Two serious bacterial infections in a two-year period (meningitis, blood infection, or pneumonia) Swelling of the parotid gland (salivary glands located in front of the ear) Oral thrush that lasts for more than two months. A yeast infection that occurs in the digestive track or lungs. Constant or recurring sinus infections. Constant or ...Jun 26, 2023 · Babies are at high risk of bacterial meningitis and often have symptoms that mimic other illnesses. Parents should be on the lookout for meningitis symptoms such as high fever, stiff neck, rigid extremities, vomiting, diarrhea, or a skin rash with lots of pinpoint-sized dots ( petechiae ) that are associated with invasive meningococcal disease . The MenB vaccine will protect your baby against infection by meningococcal group B bacteria. These bacteria are responsible for about 9 in every 10 meningococcal infections in young children. Meningococcal infections can be very serious, causing meningitis and sepsis. This can lead to severe brain damage, amputations and, sometimes, death.Side effects linked to the vaccines are usually mild and tend to go away within a few days. Herd immunity is unlikely to prevent meningitis, so it is essential that people get vaccinated and have ...purple-red skin rash or bruising. pale or blotchy skin. seizures (fits) The most common symptoms of meningitis in older children and adults are: fever. sensitivity to light. very bad headache and stiff or sore neck. nausea or vomiting and loss of appetite. tiredness and drowsiness. Trust your instincts and do not wait for all the symptoms to appear or until a rash develops. Symptoms of meningitis and sepsis include: a high temperature. cold hands and feet. vomiting. confusion. breathing quickly. muscle and joint pain. pale, mottled or blotchy skin (this may be harder to see on brown or black skin) Spread to others. People spread meningococcal bacteria to other people by sharing respiratory and throat secretions (saliva or spit). Generally, it takes close (for example, coughing or kissing) or lengthy contact to spread these bacteria. Fortunately, they are not as contagious as germs that cause the common cold or the flu. To help comfort your baby, you can: give them a cuddle; offer them extra cool drinks (if you're breastfeeding, your child may feed more often) take them for a walk in the fresh air; If the injection site is red, swollen or tender, put a clean cold cloth to the area for about 5 to 10 minutes – this may help to soothe your baby. After the MMR ...Aug 4, 2022 · Some 4% to 6% of babies with GBS disease, including meningitis, will die from their infections. Those who recover may deal with complications like: brain damage; hearing loss; Do not administer meningococcal vaccines to: A person who has ever had a severe allergic reaction (e.g., anaphylaxis) after a previous dose; A person who has a severe allergy to any vaccine component; If otherwise indicated, vaccine providers may administer meningococcal vaccines to pregnant or breastfeeding women.Spinal meningitis is inflammation of the brain and spinal cord due to an infection. Types of meningitis include viral, bacterial, fungal, parasitic, amoebic, and noninfectious. Symptoms typically include headache, fever, and neck stiffness. Treatment depends on the type of meningitis but can include antibiotics, pain relievers, or hospitalization.Feb 27, 2018 · Viral meningitis is the most common type, but it’s not usually life-threatening. The enteroviruses that cause meningitis can spread through direct contact with saliva, nasal mucus, or feces ...
In infants, meningitis symptoms may include: High fever. Crying that’s constant and gets louder when you hold the baby. Baby seems overly sleepy, sluggish, or inactive. Stiff neck or body. Bulge ... . Petr yan
Extreme fatigue. Irritability. Blue color to the skin. Babies with group B strep bacteria could get serious complications like these: Pneumonia -- a lung infection. Meningitis -- inflammation in ...Jun 15, 2022 · Meningitis can occur in people of all ages, but babies, children, and those with a weakened immune system are at the highest risk. Babies between birth and 1 month of age are more likely to ... Older children and adolescents have a stiff neck with a fever, headache, and confusion, and newborns and young infants are usually irritable, stop eating, vomit, or have other symptoms. The diagnosis is based on the results of a spinal tap and blood and urine tests. Some children die of meningitis even after receiving appropriate treatment.Meningitis in newborns can be either early or late onset. Early onset occurs within the first week after birth for babies born at term, and in the first 72 hours of life for those born preterm ...Bacterial meningitis, which took the life of famed guitar player Jeff Beck, is a potentially deadly infection that can strike quickly. Learn about the causes, what puts you at risk, and how to ...Apr 27, 2023 · Child and Adolescent Immunization Schedule by Age. Recommendations for Ages 18 Years or Younger, United States, 2023. Print. Please see the most up-to-date COVID-19 vaccine recommendations and new or updated recommendations for RSV , Influenza, pneumococcal, polio, and Mpox vaccines. These have been adopted by the CDC Director and are official. Sep 24, 2018 · Causes of meningitis in babies Viral meningitis. Viral meningitis usually isn’t as serious as bacterial or fungal meningitis, but some viruses do cause... Bacterial meningitis. Group B Streptococcus. This usually spreads from a mother to her baby at birth. Gram-negative... Fungal meningitis. Fungal ... Meningococcal meningitis and bloodstream infections can be very serious, even deadly. The infections progress quickly. Someone can go from being healthy to very ill in 48 hours or less. Even if they get treatment, about 10 to 15 in 100 people with meningococcal disease will die from it.The most common causes of bacterial meningitis among babies younger than 2 months of age are group B Streptococcus, Streptococcus pneumoniae, Listeria monocytogenes, and Escherichia coli .Meningitis signs and symptoms in babies. Your baby might not experience the same meningitis symptoms as adults (like headache, neck stiffness and nausea) and it can be hard to tell even if they are. Some signs of meningitis you can look for in babies include: Bulging “soft spot” (fontanelle) on baby’s head. Poor eating.Meningitis is characterized by inflammation of the membranes (meninges) around the brain or spinal cord. Inflammation can begin suddenly (acute) or develop gradually (subacute). Major symptoms may include fever, headache, and a stiff neck, sometimes with aching muscles. Nausea, vomiting and other symptoms may occur. View Full Report.Pregnant women who are at increased risk for serogroup A, C, W, or Y meningococcal disease may get MenACWY vaccines. Pregnant or breastfeeding women who are at increased risk for serogroup B meningococcal disease may get MenB vaccines. However, they should talk with a doctor to decide if the benefits of getting the vaccine outweigh the risks ...Meningitis is an infection of the protective membranes that surround the brain and spinal cord (meninges). It can affect anyone, but is most common in babies, young children, teenagers and young adults. Meningitis can be very serious if not treated quickly. It can cause life-threatening blood poisoning ( sepsis) and result in permanent damage ... Children can develop meningitis from close contact with a person who has the infection or through surfaces and inanimate objects infected with the germ that causes meningitis. A simple cold or...Meningitis during the neonatal period is a potentially devastating condition with dire long-term consequences. Despite advances in preventive and critical care medicine, bacterial meningitis continues to have an adverse outcome rate of 20 to 60% among its survivors.[1] Although the incidence and mortality have declined over the past few decades, it remains challenging to diagnose due to ...Jun 15, 2022 · Meningitis can occur in people of all ages, but babies, children, and those with a weakened immune system are at the highest risk. Babies between birth and 1 month of age are more likely to ... Summary. Herpes meningitis is a type of viral meningitis resulting from infection with a herpes virus. Three types of herpes virus can cause HM: herpes simplex virus 1, herpes simplex virus 2, and ...Many infections cause similar symptoms. Call your child's doctor or seek emergency medical care if your new baby shows any of these possible signs of infection: poor feeding. breathing difficulty. listlessness. decreased or elevated temperature. unusual skin rash or change in skin color. persistent crying. unusual irritability..